Rispolept,risperidona

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Rispolept,risperidona

Postby cora » Thu Sep 21, 2006 1:25 pm

Rog parintii care au administrat Rispolept copiilor , sa-mi spuna ce reactii adverse au observat .
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Postby lucian » Thu Sep 21, 2006 10:42 pm

Parerile si observatiile noastre ca parinti asupra administrarii unui medicament sunt subiective. Daca doresti un mod obiectiv de a te informa asupra Rispolept (risperidone) intra pe www.medscape.com, inregistreza-te si cauta dupa "risperidone, autism". Vei gasi suficiente studii, chiar foarte recente, articole si review-uri pe subiect.
Personal pot sa-ti spun ca timp de 2 ani de administrare la o doza de 1mg / zi nu am observat nimic din ceea ce scrie in prospectul medicamentului ca posibile reactii adverse.
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rispolept

Postby cami » Fri Nov 10, 2006 12:06 pm

www.medscape.com/viewarticle/546499

Risperidone (Risperdal) for Autism-Related Irritability in Children and Adolescents

On October 6, the FDA approved a new indication for risperidone oral solution/tablets and orally disintegrating tablets (Risperdal and Risperdal M-TAB, made by Janssen Pharmaceutica NV, a subsidiary of Johnson & Johnson]), allowing its use for the treatment of irritability associated with autistic disorder in pediatric patients aged 5 to 16 years.

The approval was based on data from two 8-week clinical trials of 156 patients aged 5 to 16 years who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for autistic disorder, showing that risperidone therapy yielded significant improvements compared with placebo as evaluated by the irritability subscale of the Aberrant Behavior Checklist (ABC-I). The ABC-I measures symptoms such as aggression towards others, deliberate self-injuriousness, temper tantrums, and quickly changing moods. The Clinical Global Impression–Change (CGI-C) scale was also used as an outcome measure in one of the studies to show significant improvement.

In addition, a study extension of patients who had achieved responder status (≥ 25% improvement on ABC-I scale and CGI-C rating of much/very much improved for about 140 days) showed that those who continued risperidone therapy demonstrated significantly lower relapse rates (defined as ≥ 25% worsening on ABC-I subscale) compared with those who were switched to placebo.

In the studies, the most commonly reported risperidone-related adverse events (incidence ≥ 5% and twice that of placebo) included somnolence; increase in appetite, fatigue, upper respiratory tract infection; increase in saliva, constipation, dry mouth, tremor, muscle stiffness, dizziness, involuntary movements, repetitive behavior, rapid heart beat, confusion; and increased weight.

The recommended dose of risperidone for autism should be individualized according to the patient's response and tolerability, according to the FDA. The total daily dose may be administered as a single dose or in 2 divided doses.

Treatment should be initiated at a dose of 0.25 mg/day for children weighing less than 20 kg, and 0.50 mg/day for those weighing 20 kg or more. After at least 4 days of therapy, risperidone doses may be increased to 0.50 mg/day (< 20 kg) and 1.0 mg/day (≥ 20 kg). If clinical response is insufficient, dose increases may be considered at 2-week or longer intervals in increments of 0.25 mg/day (< 20 kg) or 0.50 mg/day (≥ 20 kg). Caution should be exercised when dosing patients weighing less than 15 kg; therapeutic safety and efficacy have not been established in children younger than 5 years.

Once sufficient clinical response has been achieved and maintained, consideration should be given to gradually lowering the dose to achieve an optimal balance of efficacy and safety. For patients with persistent somnolence, administration of the once-daily dose at bedtime or dividing the daily dose may be of some benefit.

Risperidone was previously approved for the treatment of schizophrenia and as monotherapy or in combination with lithium or valproate for the short-term treatment of acute manic/mixed episodes associated with bipolar 1 disorder.
Horia,4ani,autism
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Postby Magister » Sat Nov 11, 2006 10:42 pm

Pagina este in general impotriva abuzului 'oficial' de medicatie, dar are si marturii partial pozitive (ex. a lui Donna Williams):
http://www.dinahm.pwp.blueyonder.co.uk/risp.htm
n.1974, recent Dx - sindrom Asperger
"Nu imi propun sa scriu o oda decaderii, ci sa ma laud cu placerea cocosului cantator dimineata, cocotat peste cuibar, chiar numai pentru a-mi trezi vecinii" Henry David Thoreau - Walden
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Postby mari » Thu Jan 04, 2007 2:32 am

lucian wrote:Parerile si observatiile noastre ca parinti asupra administrarii unui medicament sunt subiective. Daca doresti un mod obiectiv de a te informa asupra Rispolept (risperidone) intra pe www.medscape.com, inregistreza-te si cauta dupa "risperidone, autism". Vei gasi suficiente studii, chiar foarte recente, articole si review-uri pe subiect.
Personal pot sa-ti spun ca timp de 2 ani de administrare la o doza de 1mg / zi nu am observat nimic din ceea ce scrie in prospectul medicamentului ca posibile reactii adverse.


am inteles ca nu va puteti plinge de reactiile adverse...insa as vrea sa stiu mai mult privind reactiile pozitive,daca se poate

cred ca ati inceput administrarea lui dupa 5 ani,asa cum este recomandat?

am inteles eu gresit,sau este totusi considerat un anti-psihotic?
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Postby Magister » Fri Jan 05, 2007 11:27 am

Da, Risperidona este un anti-psihotic (neuroleptic) "atipic" (fata de cele mai vechi - de ex. Clorpromazina, Haloperidol - care aveau reactii adverse mai severe). E prescris in principal pentru schizofrenie.

Da, ne intereseaza marturiile parintilor (si mai ales ale pacientilor): care este efectul principal, dorit, in ce masura e util si CUI etc. Am vazut chiar pareri ca neurolepticele sunt in principal "pentru confortul anturajului" si nu ajuta efectiv persoana, ci doar nu mai lasa sa se vada problemele...

Problema cu o mare parte din studiile oficiale, "peer-reviewed" e ca studiaza DOAR ceva care ii intereseaza, o ipoteza stiintifica, aruncand deoparte informatiile "anecdotice" care totusi, cumulate, pot fi importante.
Alte studii au avut practici dubioase (a include in esantion - "screening" - doar o categorie mai ingusta, care se presupune ca va avea o reactie mai favorabila; a nu numara persoanele care renunta din cauza efectelor adverse) etc.
n.1974, recent Dx - sindrom Asperger
"Nu imi propun sa scriu o oda decaderii, ci sa ma laud cu placerea cocosului cantator dimineata, cocotat peste cuibar, chiar numai pentru a-mi trezi vecinii" Henry David Thoreau - Walden
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Postby dora » Wed Aug 25, 2010 11:57 am

A doua problema, Rispoleptul, medicamentul la care am fost initial foarte reticenta si care intr-un final l-am incercat, noua ne-a facut mai mult rau decat bine.

Partea buna a fost ca Razvan intr-adevar era mai linistit si nu avea astfel de manifestari ca cele de azi.INSA, la un moment dat s-a trezit cu gatul intepenit si a stat cu capul aplecat intr-o parte o saptamana.Am crezut ca a dormit cu gatul stramb, desi tinea capul prea aplecat inspre umar si era practic paralizat in aceea pozitie.

Am continuat sa-i dau tratamentul pana miercurea trecuta cand, brusc, intr-o dimineata cand ne duceam la gradinita, l-a lovit o hemoragie pe nas, ceva de speriat.Am ajuns cu copilul la centru pe brate, alb la fata, plin de sange, mai mult lesinat.Se pare ca aceasta reactie e tot de la Rispolept, urmeaza sa-i facem analizele la sange sa excludem altceva si sa vedem exact ce modificari hematologice s-au produs de la aceasta substanta(risperidona).Noi am mai avut un episod de trombocitopenie de la carbamazepina, asa ca nu-i de gluma cu substantele acestea.De miercuri am oprit orice tratament.

http://copilulcurcubeului.blogspot.com/
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Postby crinabm » Sun Apr 17, 2011 3:17 pm

Ca reactie adversa am observat cresterea poftei de mancare. Ca reactii pozitive am observat imbunatatirea somnului, reducerea comportamentelor agresive si o mai buna colaborare cu copilul care e esentiala atunci cand vrei sa lucrezi cu el. E foarte important sa fie cuminte si sa colaboreze pentru ca altfel nu evolueaza. Eu am avut rezultate pozitive si la 0.5mg pe zi si regret ca am avut reticente si nu i l-am administrat mai recent. Cred ca se justifica mai ales la copiii agitati, agresivi, incapatanati. Cu cat doza la care raspunde copilul e mai mica cu atat sunt reactii adverse mai mici.
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reactie la rispolept

Postby mamageorge » Sun Sep 04, 2011 11:11 pm

Nu stiu daca rispoleptul este aceeasi substanta activa ca la rispen... banuiesc ca da! Baiatul meu, care are acum 9 ani, ia o pastila de 1 mg de Torendo Q- Tab pe zi (rispen). Aceleasi imbunatatiri ale comportamentului ca cele mentionate mai sus, reuseste sa stea la scoala, este si hiperkinetic si agresiv uneori, insa pofta de mancare l-a facut sa ia 10 kg intr-un an, e si inalt, acum are 145 cm si 35 kg... PS Am scapat si de problemele cu alimentatia, mananca aproape toate felurile de mancare, inainte era tare "exclusivist"...
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Re: Rispolept,risperidona

Postby dora » Sat Oct 15, 2016 9:38 am

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